The Set Up
When you receive your bike, the most important thing is the original set-up. If you receive it brand new, there will be a number of things you will need to attach, tighten, and adjust.
Body Panels: Frequently, one or more body panels will be shipped loose with your bike. It is important to attach them securely and correctly to the frame. Be sure not to over-tighten the bolts, as they may cause the body panels to crack.
Frame & Controls: It is very important to inspect and tighten all frame bolts (especially the handlebars) prior to 1st use, and regularily thereafter.
The most critical time period to owning a crotch rocket is the break in period. When an engine, especially a tiny, high-power engine, runs, it wears in. The inside of the cylinder gets some tear as it aligns with the piston, piston ring. If you are interested in reading more about engine break-in, this is a great aricle. Asian rockets usually take an oil/gasoline premix ratio of 25:1, an equivalent of 5 fl oz to 1 gal of gas. European bikes, however, usually specify a leaner ratio. It is important to not only follow the manufacturer's recommended oil ratios, but to observe what kind of oil you use.
The initial break in period is just as important for the rest of your bike as it is for the engine. It is important that you check all fasteners after every few minutes of riding. Ensure that the frame bolts are secure, as well as those on the wheels and other parts of your bike. Rough terrain and the weight of you on your bike will cause the frame to settle, and all connections must be tightened.
Two cycle rocket engines do not need certain kinds of maintenance you may be used to, such as draining liquids or changing oil. The engine receives its lubrication from the two-cycle oil you pre-mix into the gasoline before filling up the gas tank. You only add a small amount of oil to the gas, and this oil is burned during the normal combustion cycle (every other stroke, hence the name, 2-stroke), lubricating the inner parts of the engine. The burned oil, over time, can accumulate around the engine exhaust.